PINWORM

 

PINWORM

 

DEFINITION:

A nematode which infects the intestines and causes perianal irritation.

EPIDEMIOLOGY:

  • incidence: 5-15% of the population
  • age of onset:
    • any age with peak between 5-14 years of age
  • risk factors:
    • preschool and school-age children

PATHOGENESIS:

1. Background

  • pinworm (Enterobius vermicularis) eggs are ingested and migrate to the duodenum where they hatch, mature, and then travel to the cecum; the adult females emerge at night through the anus and deposit their eggs in the perianal region then die; the eggs stick to the skin and cause perianal pruritis -> scratching -> accumulation of the eggs under the fingernails -> autoinfection and spread
  • the eggs may also fall off the skin into the underclothing, pajamas, or sheets where they remain viable for 3-4 weeks
  • the eggs may be acquired by direct contact with contaminated areas but to be infectious the eggs must be swallowed
  • man is the only natural host to pinworms
  • the pinworms appear as 1 cm long, white, thread-like worms while the ova are asymmetric with a flattened side and measure 30 x 60 um

CLINICAL FEATURES:

1. Gastrointestinal Manifestations

  • nocturnal anal pruritis

2. Other Manifestations

  • vaginitis
  • salpingitis

INVESTIGATIONS:

1. Diagnostic

  • apply adhesive cellophane tape to the perianal region early in the morning upon awakening -> apply the tape to a glass slide and look for the eggs under a low power microscope

MANAGEMENT:

1. Supportive

  • all household members should wash their hands after using the toilet, changing diapers, and while preparing or eating food
  • trim fingernails of all those affected

2. Medical

1. Mebendazole (Vermox)

  • drug of first choice
  • 100 mg po once then again after 2 weeks
  • may treat all household members
  • interfere with larval development
  • contraindications:
    • hypersensitivity to the drug
    • children less than 2 years of age (may cause seizures in children less than 1 year of age)

2. Pyrantel Pamoate (Combantrin)

  • drug of second choice
  • 11 mg/kg po once then again after 2 weeks
  • may treat all household members
  • do not use in children less than 1 year of age

REFERENCES:

  • 1. Pediatrics in Review 16(7): 247 (1995)
  • 2. Canadian Journal of Paediatrics 2(3): 317 (1995)
  • 3. Nelson Textbook of Pediatrics 14th Edition, p. 898-899 (1992)
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    Pediatric Database - PINWORM

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