PEDBASE.org - The Pediatric Database - Detailed information of GASTROINTESTINAL POLYPOSIS

GASTROINTESTINAL POLYPOSIS

DEFINITION:

A disorder involving the colon characterized by masses of benign inflammatory polyps mixed with potentially malignant adenomatous polyps.

EPIDEMIOLOGY:

incidence: ?
age of onset:
- older than 10 years of age
risk factors:
- familial - autosomal dominant or sporadic
  - chrom.#: ?
  - gene: ?

PATHOGENESIS:

1. Background

Juvenile Polyposis Syndrome is classified into three disorders each associated with inflammatory polyps:
1. Juvenile Polyposis of Infancy

2. Juvenile Polyposis Coli

3. Gastrointestinal Polyposis

CLINICAL FEATURES:

1. Gastrointestinal Manifestations

1. Painless Rectal Bleeding

+/- bloody diarrhea

2. Others

recurrent epigastric pain

3. Complications

malignancy potential: malignancy of stomach, duodenum, cecum, and rectum

INVESTIGATIONS:

1. Colonoscopy

procedure of choice

2. Imaging Studies

barium enema with air contrast (Double Contrast)

3. Biopsy

inflammatory +/- adenomatous polyps
areas affected: colon and stomach

4. Serum

microcytic hypochromic anemia
reduced serum iron and ferritin with elevated transferrin

MANAGEMENT:

1. Supportive

iron supplementation for anemia
nutritional support

2. Surgery

if indicated
snare-loop polypectomy with diathermy

Pediatric Database - GASTROINTESTINAL POLYPOSIS

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