CONSTIPATION

 

CONSTIPATION

 

DEFINITION:

The infrequent passage of stool.

EPIDEMIOLOGY:

  • incidence: common
  • age of onset:
    • first year (60%)
  • risk factors:
    • see differential diagnosis

DIFFERENTIAL DIAGNOSIS:

1. Diet

  • introduction of cow's milk
  • inadequate fluid intake
  • undernutrition
  • high CHO and/or protein diet
  • low fibre diet

2. Organic

1. Diseases causing abnormally dry stool

  • Diabetes Insipidus/Mellitus
  • Fanconi Syndrome
  • Idiopathic Hypercalcemia

2. CNS Lesions

  • hypotonia (Benign Congenital Hypotonia)
  • hypertonia (Cerebral Palsy)
  • Infectious Polyneuritis/Poliomyelitis
  • myelodysplasias

3. Gastrointestinal Anomalies

  • Hirschsprung Disease
  • anorectal stenotic lesions, strictures, fissures
  • masses (intrinsic, extrinsic)
  • anterior anal displacement

4. Others

  • Hypothyroidism
  • Prune-Belly Syndrome

3. Social/Medical

  • "psychogenic constipation" - inadequately managed acute problem
  • coercise toilet training
  • at school or camp

HISTORY:

  • history of drugs (diuretics, antidepressants, antispasmodics)
  • constipation since birth (Hirschsprung Disease)
  • concurrent bladder incontinence or abnormal anal tone (neurologic)
  • hypothyroidism (dry skin, lethargy, slowing growing hair and nails)
  • assess height for short stature (can't touch floor)
  • 99% of constipation is idiopathic
  • look for a precipitating event (anal fissure)

CLINICAL FEATURES:

  • constipation +/- abdominal pain
  • complications:
    • overflow incontinence with fecal soiling ("diarrhea")
    • impaction with chronic dilatation
    • UTI +/- vesicoureteral reflux
    • intestinal obstruction

INVESTIGATIONS:

1. Imaging Studies

  • abdominal x-rays may show rectal/rectosigmoid impaction and a rectosigmoid index of < 1 (normal > 1)

2. Sigmoidoscopy

  • with biopsy for Hirschrung Disease

MANAGEMENT:

1. Options

1. Bulk (soluble fibres)

  • bran - oat, wheat
  • psyllium - Metamucil, ProDiem

2. Osmotics

  • magnesium - Milk of Magnesia, Epsin Salts
  • phosphate - fleet enemas
  • sugars - lactulose, sorbitol (gas, acidic stool)
  • PEG - Go Litely

3. Stimulants

  • phenolphthalein
  • Senna, aloe, rhubarb
  • castor oil
  • bisacodyl

4. Stool Softeners

  • SDS

5. Lubricants

  • mineral oil, glycerine

6. Enemas

  • Note: In the treatment of constipation in children, there appears to be no role for stimulants, stool softeners, lubricants, or enemas.

2. Management in Children

1. Rule out organic causes

2. Explain pathophysiology to family and patient

  • draw out GI system and explain how stool is formed
  • explain mechanism of constipation
    • use analogy of boxcars
    • use "I gotta go valve" and "not now valve"
  • explain the 3 steps needed to correct the constipation
    • no quick fix and in for the long haul with follow ups
    • compliance is vital so fun foods are important
    • parents, doctor, and child must have a health attitude
    • may keep a stool diary to be reviewed on follow-up

3. Phase I - Clean Out Phase:

  • to empty the bowel from above or below

1. Polyethylene Glycol (PEG)

  • 2-4 litres over 2-3 days
  • mix with Tropical Punch Kool-aid
    • 5 scoops of Kool-aid to 1 litre of PEG
    • will come out the same colour as flavoured PEG
    • PEG is not thirst quenching so child will continue to drink throughout the day
    • try to buy in 1 litre jugs
  • may also mix with frozen orange juice
  • will be an initial liquid phase -> solid phase -> then another liquid phase or

2. Hypertonic Phosphate Enemas

  • three times over 36-48 hours

4. Phase II - Maintenance (Training) Phase:

  • to allow the bowel to return to normal size

1. Milk of Magnesia (MM)

  • 1 tbsp. po bid -> qid
  • enough to give 1-2 loose stools per day everyday x 1 month
  • may start during initial Clean Out Phase
  • give between meals to avoid fat-soluble vitamin absorption problems
  • comes in many different flavours and

2. Oat Bran

  • 2/3 cup oatbran + 1 cup of water
  • microwave at 100% x 2 min + at 20% x 10 min
  • add brown sugar, milk, strawberry cow, peaches, etc. or

3. Metamucil plain or ProDiem plain

  • 1 tbsp. po od
  • add Metamucil to peanut butter and jam sandwiches, soups, mashed potatoes
  • may make homemade jams with psyllium instead of pectin
  • sprinkle ProDiem on Ice Cream or puddings
  • sit on toilet with proper foot support for 5 minutes after breakfast and after the evening meal (gastrocolic reflex)

5. Phase III - Tapering Phase:

  • reduce MM by 20% monthly
  • follow-up:
    • should see improvement in appetite, activity and school performance

 

 

 

Pediatric Database - CONSTIPATION

Pediatric Organization - Pedbase [at] Gmail.com